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Unfolding of quadruplex structure in the G-rich strand of the minisatellite repeat by the binding protein UP1

The mouse hypervariable minisatellite (MN) Pc-1 consists of tandem repeats of d(GGCAG) and flanked sequences. We have previously demonstrated that single-stranded d(GGCAG)(n) folds into the intramolecular folded-back quadruplex structure under physiological conditions. Because DNA polymerase progres...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Fukuda, Hirokazu, Katahira, Masato, Tsuchiya, Naoto, Enokizono, Yoshiaki, Sugimura, Takashi, Nagao, Minako, Nakagama, Hitoshi
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC130521/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12235355/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.152456899
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