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A Ring of Negative Charges in the Intracellular Vestibule of Kir2.1 Channel Modulates K(+) Permeation
The glutamate at site 224 of a Kir2.1 channel plays an important role in K(+) permeation. The single-channel inward current flickers with reduced conductance in an E224G mutant. We show that open-channel fluctuations can also be observed in E224C, E224K, and E224Q mutants. Yet, open-channel fluctuat...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Biophysical Society
2005
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1305002/ https://ncbi.nlm.nih.gov/pubmed/15516518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.052217 |
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