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Oligomerization of Amyloid Aβ(16–22) Peptides Using Hydrogen Bonds and Hydrophobicity Forces
The 16–22 amino-acid fragment of the β-amyloid peptide associated with the Alzheimer's disease, Aβ, is capable of forming amyloid fibrils. Here we study the aggregation mechanism of Aβ(16–22) peptides by unbiased thermodynamic simulations at the atomic level for systems of one, three, and six A...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Biophysical Society
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1304880/ https://ncbi.nlm.nih.gov/pubmed/15377534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.046839 |
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