Permeation Properties of an Engineered Bacterial OmpF Porin Containing the EEEE-Locus of Ca(2+) Channels

The selectivity filter of the bacterial porin OmpF carries a small net charge close to −1 e and is therefore only slightly cation-selective. Calcium channels, on the other hand, contain four negatively charged glutamates, the EEEE-locus, and are among the most selective cation channels known. We aim...

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Autori principali: Miedema, Henk, Meter-Arkema, Anita, Wierenga, Jenny, Tang, John, Eisenberg, Bob, Nonner, Wolfgang, Hektor, Hans, Gillespie, Dirk, Meijberg, Wim
Natura: Artigo
Lingua:Inglês
Pubblicazione: Biophysical Society 2004
Soggetti:
Channels, Receptors, and Electrical Signaling
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304784/
https://ncbi.nlm.nih.gov/pubmed/15326033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.041384
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