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Revisiting Voltage-Dependent Relief of Block in Ion Channels: A Mechanism Independent of Punchthrough

Voltage dependence of block was investigated in a simple model for permeation in a multiion pore. Internal blocker could bind to three states of the open channel that differed in the locations and number of permeant ion bound; blocker dissociation occurs exclusively to the internal solution, and the...

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Detalhes bibliográficos
Main Authors: Heginbotham, Lise, Kutluay, Esin
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304268/
https://ncbi.nlm.nih.gov/pubmed/15189863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.103.039412
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