Electrostatic Sequestration of PIP(2) on Phospholipid Membranes by Basic/Aromatic Regions of Proteins

The basic effector domain of myristoylated alanine-rich C kinase substrate (MARCKS), a major protein kinase C substrate, binds electrostatically to acidic lipids on the inner leaflet of the plasma membrane; interaction with Ca(2+)/calmodulin or protein kinase C phosphorylation reverses this binding....

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Bibliographic Details
Main Authors: Gambhir, Alok, Hangyás-Mihályné, Gyöngyi, Zaitseva, Irina, Cafiso, David S., Wang, Jiyao, Murray, Diana, Pentyala, Srinivas N., Smith, Steven O., McLaughlin, Stuart
Format: Artigo
Language:Inglês
Published: Biophysical Society 2004
Subjects:
Membranes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304070/
https://ncbi.nlm.nih.gov/pubmed/15041659
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