First Principles Predictions of the Structure and Function of G-Protein-Coupled Receptors: Validation for Bovine Rhodopsin

G-protein-coupled receptors (GPCRs) are involved in cell communication processes and with mediating such senses as vision, smell, taste, and pain. They constitute a prominent superfamily of drug targets, but an atomic-level structure is available for only one GPCR, bovine rhodopsin, making it diffic...

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Hauptverfasser: Trabanino, Rene J., Hall, Spencer E., Vaidehi, Nagarajan, Floriano, Wely B., Kam, Victor W. T., Goddard, William A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Biophysical Society 2004
Schlagworte:
Biophysical Theory and Modeling
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304048/
https://ncbi.nlm.nih.gov/pubmed/15041637
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