Predicted 3D structure for the human β2 adrenergic receptor and its binding site for agonists and antagonists

We report the 3D structure of human β2 adrenergic receptor (AR) predicted by using the MembStruk first principles method. To validate this structure, we use the HierDock first principles method to predict the ligand-binding sites for epinephrine and norepinephrine and for eight other ligands, includ...

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Détails bibliographiques
Auteurs principaux: Freddolino, Peter L., Kalani, M. Yashar S., Vaidehi, Nagarajan, Floriano, Wely B., Hall, Spencer E., Trabanino, Rene J., Kam, Victor Wai Tak, Goddard, William A.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2004
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC365690/
https://ncbi.nlm.nih.gov/pubmed/14981238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308751101
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