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Anion Pathway and Potential Energy Profiles along Curvilinear Bacterial ClC Cl(−) Pores: Electrostatic Effects of Charged Residues

X-ray structures permit theoretical study of Cl(−) permeation along bacterial ClC Cl(−) pores. We determined the lowest energy curvilinear pathway, identified anion-coordinating amino acids, and calculated the electrostatic potential energy profiles. We find that all four bacterial ClC Cl(−) crystal...

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Main Authors: Miloshevsky, Gennady V., Jordan, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado: Biophysical Society 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303930/
https://ncbi.nlm.nih.gov/pubmed/14747318
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