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Effects of Base Substitutions in an RNA Hairpin from Molecular Dynamics and Free Energy Simulations

Contributions of individual interactions in the GGCGCAAGCC hairpin containing a GCAA tetraloop were studied by computer simulations using base substitutions. The G in the first tetraloop position was replaced by inosine (I) or adenosine (A), and the G in the C-G basepair closing the tetraloop was re...

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Bibliografische gegevens
Hoofdauteurs: Sarzynska, Joanna, Nilsson, Lennart, Kulinski, Tadeusz
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Biophysical Society 2003
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303653/
https://ncbi.nlm.nih.gov/pubmed/14645041
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