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Stability and Cu(II) Binding of Prion Protein Variants Related to Inherited Human Prion Diseases

All inherited forms of human prion diseases are linked with mutations in the prion protein (PrP) gene. Here we have investigated the stability and Cu(II) binding properties of three recombinant variants of murine full-length PrP(23–231)-containing destabilizing point mutations that are associated wi...

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Bibliografische gegevens
Hoofdauteurs: Cereghetti, Grazia M., Schweiger, Arthur, Glockshuber, Rudi, Van Doorslaer, Sabine
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Biophysical Society 2003
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302768/
https://ncbi.nlm.nih.gov/pubmed/12609901
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