Stability and Cu(II) Binding of Prion Protein Variants Related to Inherited Human Prion Diseases

All inherited forms of human prion diseases are linked with mutations in the prion protein (PrP) gene. Here we have investigated the stability and Cu(II) binding properties of three recombinant variants of murine full-length PrP(23–231)-containing destabilizing point mutations that are associated wi...

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Bibliografiske detaljer
Main Authors: Cereghetti, Grazia M., Schweiger, Arthur, Glockshuber, Rudi, Van Doorslaer, Sabine
Format: Artigo
Sprog:Inglês
Udgivet: Biophysical Society 2003
Fag:
Spectroscopy, Imaging, Other Techniques
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302768/
https://ncbi.nlm.nih.gov/pubmed/12609901
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