Quantifying Double-Strand Breaks and Clustered Damages in DNA by Single-Molecule Laser Fluorescence Sizing

Fluorescence from a single DNA molecule passing through a laser beam is proportional to the size (contour length) of the molecule, and molecules of different sizes can be counted with equal efficiencies. Single-molecule fluorescence can thus determine the average length of the molecules in a sample...

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Autori principali: Filippova, Elena M., Monteleone, Denise C., Trunk, John G., Sutherland, Betsy M., Quake, Stephen R., Sutherland, John C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Biophysical Society 2003
Soggetti:
Spectroscopy, Imaging, Other Techniques
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302704/
https://ncbi.nlm.nih.gov/pubmed/12547808
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