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Highly Accurate Classification of Watson-Crick Basepairs on Termini of Single DNA Molecules

We introduce a computational method for classification of individual DNA molecules measured by an α-hemolysin channel detector. We show classification with better than 99% accuracy for DNA hairpin molecules that differ only in their terminal Watson-Crick basepairs. Signal classification was done in...

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Detalhes bibliográficos
Main Authors: Winters-Hilt, Stephen, Vercoutere, Wenonah, DeGuzman, Veronica S., Deamer, David, Akeson, Mark, Haussler, David
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302674/
https://ncbi.nlm.nih.gov/pubmed/12547778
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