Highly Accurate Classification of Watson-Crick Basepairs on Termini of Single DNA Molecules

We introduce a computational method for classification of individual DNA molecules measured by an α-hemolysin channel detector. We show classification with better than 99% accuracy for DNA hairpin molecules that differ only in their terminal Watson-Crick basepairs. Signal classification was done in...

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Main Authors: Winters-Hilt, Stephen, Vercoutere, Wenonah, DeGuzman, Veronica S., Deamer, David, Akeson, Mark, Haussler, David
Format: Artigo
Jezik:Inglês
Izdano: Biophysical Society 2003
Teme:
Channels, Receptors, and Transporters
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302674/
https://ncbi.nlm.nih.gov/pubmed/12547778
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