Interactions of the C-11 Hydroxyl of Tetrodotoxin with the Sodium Channel Outer Vestibule

The highly selective sodium channel blocker, tetrodotoxin (TTX) has been instrumental in characterization of voltage-gated sodium channels. TTX occludes the ion-permeation pathway at the outer vestibule of the channel. In addition to a critical guanidinium group, TTX possesses six hydroxyl groups, w...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Choudhary, Gaurav, Yotsu-Yamashita, Mari, Shang, Lisa, Yasumoto, Takeshi, Dudley, Samuel C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Biophysical Society 2003
Aiheet:
Channels, Receptors, and Transporters
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302610/
https://ncbi.nlm.nih.gov/pubmed/12524282
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