Functional characterization of the type 1 inositol 1,4,5-trisphosphate receptor coupling domain SII(+/-) splice variants and the Opisthotonos mutant form.

The type 1 inositol (1,4,5)-trisphosphate receptor (InsP3R1) plays a critical role in Ca2+ signaling in cells. Neuronal and nonneuronal isoforms of the InsP3R1 differ by alternative splicing in the coupling domain of the InsP3R1 (SII site). Deletion of 107 amino acids from the coupling domain of the...

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Main Authors: Tu, Huiping, Miyakawa, Tomoya, Wang, Zhengnan, Glouchankova, Lyuba, Iino, Masamitsu, Bezprozvanny, Ilya
格式: Artigo
語言:Inglês
出版: 2002
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301995/
https://ncbi.nlm.nih.gov/pubmed/11916857
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