Functional characterization of the type 1 inositol 1,4,5-trisphosphate receptor coupling domain SII(+/-) splice variants and the Opisthotonos mutant form.

The type 1 inositol (1,4,5)-trisphosphate receptor (InsP3R1) plays a critical role in Ca2+ signaling in cells. Neuronal and nonneuronal isoforms of the InsP3R1 differ by alternative splicing in the coupling domain of the InsP3R1 (SII site). Deletion of 107 amino acids from the coupling domain of the...

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Autori principali: Tu, Huiping, Miyakawa, Tomoya, Wang, Zhengnan, Glouchankova, Lyuba, Iino, Masamitsu, Bezprozvanny, Ilya
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2002
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301995/
https://ncbi.nlm.nih.gov/pubmed/11916857
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