Heparan sulfate biosynthesis: a theoretical study of the initial sulfation step by N-deacetylase/N-sulfotransferase.

Heparan sulfate N-deacetylase/N-sulfotransferase (NDST) catalyzes the deacetylation and sulfation of N-acetyl-D-glucosamine residues of heparan sulfate, a key step in its biosynthesis. Recent crystallographic and mutational studies have identified several potentially catalytic residues of the sulfot...

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Bibliographic Details
Main Authors: Gorokhov, A, Perera, L, Darden, T A, Negishi, M, Pedersen, L C, Pedersen, L G
Format: Artigo
Language:Inglês
Published: 2000
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301170/
https://ncbi.nlm.nih.gov/pubmed/11106599
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