Actinomycin D binds strongly to d(CGACGACG) and d(CGTCGTCG).

Earlier calorimetric studies had indicated that despite the absence of a GpC sequence, the self-complementary octamer d(CGTCGACG) binds strongly to actinomycin D (ACTD) with high cooperativity and a 2:1 drug/duplex ratio. A subsequent optical spectral study with related oligomers led us to suggest t...

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Bibliographic Details
Main Authors: Sha, F, Chen, F M
Format: Artigo
Language:Inglês
Published: 2000
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301099/
https://ncbi.nlm.nih.gov/pubmed/11023913
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