Binding of Actinomycin D to Single-Stranded DNA of Sequence Motifs d(TGTCT(n)G) and d(TGT(n)GTCT)

Our recent binding studies with oligomers derived from base replacements on d(CGTCGTCG) had led to the finding that actinomycin D (ACTD) binds strongly to d(TGTCATTG) of apparent single-stranded conformation without GpC sequence. A fold-back binding model was speculated in which the planar phenoxazo...

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Bibliographic Details
Main Authors: Chen, Fu-Ming, Sha, Feng, Chin, Ko-Hsin, Chou, Shan-Ho
Format: Artigo
Language:Inglês
Published: Biophysical Society 2003
Subjects:
Nucleic Acids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302624/
https://ncbi.nlm.nih.gov/pubmed/12524296
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