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Residues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities.

Batrachotoxin (BTX) alters the gating of voltage-gated Na(+) channels and causes these channels to open persistently, whereas local anesthetics (LAs) block Na(+) conductance. The BTX and LA receptors have been mapped to several common residues in D1-S6 and D4-S6 segments of the Na(+) channel alpha-s...

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Detalhes bibliográficos
Main Authors: Wang, S Y, Nau, C, Wang, G K
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301032/
https://ncbi.nlm.nih.gov/pubmed/10969000
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