Electrostatic interactions regulate desensitization of the nicotinic acetylcholine receptor.

To determine the importance of electrostatic interactions for agonist binding to the nicotinic acetylcholine receptor (AChR), we examined the affinity of the fluorescent agonist dansyl-C6-choline for the AChR. Increasing ionic strength decreased the binding affinity in a noncompetitive manner and in...

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Detalles Bibliográficos
Main Authors: Song, X Z, Pedersen, S E
Formato: Artigo
Idioma:Inglês
Publicado: 2000
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1300732/
https://ncbi.nlm.nih.gov/pubmed/10692319
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