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Tonic and phasic tetrodotoxin block of sodium channels with point mutations in the outer pore region.

Tonic and use-dependent block by tetrodotoxin (TTX) has been studied in cRNA-injected Xenopus oocytes expressing mutants W386Y, E945Q, D1426K, and D1717Q, of the outer-pore region of the rat brain IIA alpha-subunit of sodium channels. The various phenotypes are tonically half-blocked at TTX concentr...

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Detalhes bibliográficos
Main Authors: Boccaccio, A, Moran, O, Imoto, K, Conti, F
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1300324/
https://ncbi.nlm.nih.gov/pubmed/10388752
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