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Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block
Voltage-gated Na(+) current is reduced by acid solution. Protons reduce peak Na(+) conductance by lowering single channel conductance and shift the voltage range of gating by neutralizing surface charges. Structure-function studies identify six carboxyls and a lysine in the channel's outer vest...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2290475/ https://ncbi.nlm.nih.gov/pubmed/12181282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.021014 |
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