Conditional gene knock-down by CRE-dependent short interfering RNAs

Short interfering RNAs (siRNAs) are short (21–23 nt) double-stranded RNAs that direct the sequence-specific degradation of corresponding mRNAs, resulting in suppression of gene activity. siRNAs are powerful tools for gene functional analysis in mammals. Chemically synthesized siRNAs permit transient...

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Bibliografiske detaljer
Main Authors: Fritsch, Lauriane, Martinez, Luis A, Sekhri, Redha, Naguibneva, Irina, Gérard, Mathieu, Vandromme, Marie, Schaeffer, Laurent, Harel-Bellan, Annick
Format: Artigo
Sprog:Inglês
Udgivet: 2004
Fag:
Scientific Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1298975/
https://ncbi.nlm.nih.gov/pubmed/14726950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400064
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