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The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expression

The 3′ Ig heavy chain locus (Igh) regulatory region is the most downstream known element of the murine Igh gene cluster. We report here that the nearest non-Igh genes—Crip, Crp2, and Mta1—are located ≈70 kb further downstream and are beyond the end of the domain of Igh transcriptional regulation. We...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Zhou, Jie, Ashouian, Nasrin, Delepine, Marc, Matsuda, Fumihiko, Chevillard, Christophe, Riblet, Roy, Schildkraut, Carl L., Birshtein, Barbara K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129745/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12370427/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.212392399
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