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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that occurs upon mutation of either the TSC1 or TSC2 genes, which encode the protein products hamartin and tuberin, respectively. Here, we show that hamartin and tuberin function together to inhibit mammalian target of rapamy...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Tee, Andrew R., Fingar, Diane C., Manning, Brendan D., Kwiatkowski, David J., Cantley, Lewis C., Blenis, John
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129715/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12271141/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.202476899
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