Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that occurs upon mutation of either the TSC1 or TSC2 genes, which encode the protein products hamartin and tuberin, respectively. Here, we show that hamartin and tuberin function together to inhibit mammalian target of rapamy...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Tee, Andrew R., Fingar, Diane C., Manning, Brendan D., Kwiatkowski, David J., Cantley, Lewis C., Blenis, John
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2002
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129715/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12271141/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.202476899
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