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Folding free energy function selects native-like protein sequences in the core but not on the surface
An automatic protein design procedure is used to select amino acid sequences that optimize the folding free energy function for a given protein. The only information used in designing the sequences is a set of known backbone structures for each protein, a rotamer library, and a well established clas...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The National Academy of Sciences
2002
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC129712/ https://ncbi.nlm.nih.gov/pubmed/12368470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212068599 |
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