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The structural basis for the transition from Ras-GTP to Ras-GDP

The conformational changes in Ras that accompany the hydrolysis of GTP are critical to its function as a molecular switch in signaling pathways. Understanding how GTP is hydrolyzed by revealing the sequence of intermediary structures in the reaction is essential for understanding Ras signaling. Unti...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Principais autores: Hall, Brian E., Bar-Sagi, Dafna, Nassar, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2002
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129411/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12213964/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.192453199
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