Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

Optimal activation of T cells requires effective occupancy of both the antigen-specific T cell receptor and a second coreceptor such as CD28. We used cDNA microarrays to characterize the genomic expression program in human peripheral T cells responding to stimulation of these receptors. We found tha...

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Detalhes bibliográficos
Main Authors: Diehn, Maximilian, Alizadeh, Ash A., Rando, Oliver J., Liu, Chih Long, Stankunas, Kryn, Botstein, David, Crabtree, Gerald R., Brown, Patrick O.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC129348/
https://ncbi.nlm.nih.gov/pubmed/12195013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.092284399
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