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Evidence for an ancient selective sweep in the MHC class I gene repertoire of chimpanzees

MHC class I molecules play an essential role in the immune defense against intracellular infections. The hallmark of the MHC is its extensive degree of polymorphism at the population level. However, the present comparison of MHC class I gene intron variation revealed that chimpanzees have experience...

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Autors principals: de Groot, Natasja G., Otting, Nel, Doxiadis, Gaby G. M., Balla-Jhagjhoorsingh, Sunita S., Heeney, Jonathan L., van Rood, Jon J., Gagneux, Pascal, Bontrop, Ronald E.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2002
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC129340/
https://ncbi.nlm.nih.gov/pubmed/12186979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182420799
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