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Evidence for an ancient selective sweep in the MHC class I gene repertoire of chimpanzees

MHC class I molecules play an essential role in the immune defense against intracellular infections. The hallmark of the MHC is its extensive degree of polymorphism at the population level. However, the present comparison of MHC class I gene intron variation revealed that chimpanzees have experience...

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Detalhes bibliográficos
Main Authors: de Groot, Natasja G., Otting, Nel, Doxiadis, Gaby G. M., Balla-Jhagjhoorsingh, Sunita S., Heeney, Jonathan L., van Rood, Jon J., Gagneux, Pascal, Bontrop, Ronald E.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC129340/
https://ncbi.nlm.nih.gov/pubmed/12186979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182420799
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