Evidence for an ancient selective sweep in the MHC class I gene repertoire of chimpanzees

MHC class I molecules play an essential role in the immune defense against intracellular infections. The hallmark of the MHC is its extensive degree of polymorphism at the population level. However, the present comparison of MHC class I gene intron variation revealed that chimpanzees have experience...

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Main Authors: de Groot, Natasja G., Otting, Nel, Doxiadis, Gaby G. M., Balla-Jhagjhoorsingh, Sunita S., Heeney, Jonathan L., van Rood, Jon J., Gagneux, Pascal, Bontrop, Ronald E.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC129340/
https://ncbi.nlm.nih.gov/pubmed/12186979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182420799
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