Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution

Humans are genetically deficient in the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an Alu-mediated inactivating mutation of the gene encoding the enzyme CMP-N-acetylneuraminic acid (CMP-Neu5Ac) hydroxylase (CMAH). This mutation occurred after our last common ancestor...

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Detalhes bibliográficos
Main Authors: Chou, Hsun-Hua, Hayakawa, Toshiyuki, Diaz, Sandra, Krings, Matthias, Indriati, Etty, Leakey, Meave, Paabo, Svante, Satta, Yoko, Takahata, Naoyuki, Varki, Ajit
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC129338/
https://ncbi.nlm.nih.gov/pubmed/12192086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182257399
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