Dosage-Dependent Effects of Akt1/Protein Kinase Bα (PKBα) and Akt3/PKBγ on Thymus, Skin, and Cardiovascular and Nervous System Development in Mice

Akt/protein kinase B (PKB) plays a critical role in the regulation of metabolism, transcription, cell migration, cell cycle progression, and cell survival. The existence of viable knockout mice for each of the three isoforms suggests functional redundancy. We generated mice with combined mutant alle...

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Main Authors: Yang, Zhong-Zhou, Tschopp, Oliver, Di-Poï, Nicolas, Bruder, Elisabeth, Baudry, Anne, Dümmler, Bettina, Wahli, Walter, Hemmings, Brian A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1291243/
https://ncbi.nlm.nih.gov/pubmed/16287854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.23.10407-10418.2005
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