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Baculovirus apoptotic suppressor P49 is a substrate inhibitor of initiator caspases resistant to P35 in vivo

Caspases play a critical role in the execution of metazoan apoptosis and are thus attractive therapeutic targets for apoptosis-associated diseases. Here we report that baculovirus P49, a homolog of pancaspase inhibitor P35, prevents apoptosis in invertebrates by inhibiting an initiator caspase that...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zoog, Stephen J., Schiller, Jennifer J., Wetter, Justin A., Chejanovsky, Nor, Friesen, Paul D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2002
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC129042/
https://ncbi.nlm.nih.gov/pubmed/12356729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf520
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