Baculovirus apoptotic suppressor P49 is a substrate inhibitor of initiator caspases resistant to P35 in vivo

Eitemau Tebyg

• Crystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibition.
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• The apoptotic suppressor P35 is required early during baculovirus replication and is targeted to the cytosol of infected cells.
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• Baculovirus Caspase Inhibitors P49 and P35 Block Virus-Induced Apoptosis Downstream of Effector Caspase DrICE Activation in Drosophila melanogaster Cells
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  Cyhoeddwyd: (2007)
• Baculovirus inhibitor of apoptosis functions at or upstream of the apoptotic suppressor P35 to prevent programmed cell death.
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• Reactive-Site Cleavage Residues Confer Target Specificity to Baculovirus P49, a Dimeric Member of the P35 Family of Caspase Inhibitors
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  Cyhoeddwyd: (2008)