CD4(+) T cell–independent DNA vaccination against opportunistic infections

Depletion or dysfunction of CD4(+) T lymphocytes profoundly perturbs host defenses and impairs immunogenicity of vaccines. Here, we show that plasmid DNA vaccination with a cassette encoding antigen (OVA) and a second cassette encoding full-length CD40 ligand (CD40L), a molecule expressed on activat...

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Detaylı Bibliyografya
Asıl Yazarlar: Zheng, Mingquan, Ramsay, Alistair J., Robichaux, Myles B., Norris, Karen A., Kliment, Corrine, Crowe, Christopher, Rapaka, Rekha R., Steele, Chad, McAllister, Florencia, Shellito, Judd E., Marrero, Luis, Schwarzenberger, Paul, Zhong, Qiu, Kolls, Jay K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2005
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1288835/
https://ncbi.nlm.nih.gov/pubmed/16308571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26306
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