CD4(+) T cell–independent DNA vaccination against opportunistic infections

Depletion or dysfunction of CD4(+) T lymphocytes profoundly perturbs host defenses and impairs immunogenicity of vaccines. Here, we show that plasmid DNA vaccination with a cassette encoding antigen (OVA) and a second cassette encoding full-length CD40 ligand (CD40L), a molecule expressed on activat...

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Detalhes bibliográficos
Main Authors: Zheng, Mingquan, Ramsay, Alistair J., Robichaux, Myles B., Norris, Karen A., Kliment, Corrine, Crowe, Christopher, Rapaka, Rekha R., Steele, Chad, McAllister, Florencia, Shellito, Judd E., Marrero, Luis, Schwarzenberger, Paul, Zhong, Qiu, Kolls, Jay K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1288835/
https://ncbi.nlm.nih.gov/pubmed/16308571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26306
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