Are There Low-Penetrance TP53 Alleles? Evidence from Childhood Adrenocortical Tumors

We have analyzed a panel of 14 cases of childhood adrenocortical tumors unselected for family history and have identified germline TP53 mutations in >80%, making this the highest known incidence of a germline mutation in a tumor-suppressor gene in any cancer. The spectrum of germline TP53 mutatio...

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Huvudupphovsmän: Varley, Jennifer M., McGown, Gail, Thorncroft, Mary, James, Louise A., Margison, Geoffrey P., Forster, Gill, Evans, D. Gareth R., Harris, Martin, Kelsey, Anna M., Birch, Jillian M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society of Human Genetics 1999
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1288270/
https://ncbi.nlm.nih.gov/pubmed/10486318
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