A schizophrenia-related sensorimotor deficit links α3-containing GABA(A) receptors to a dopamine hyperfunction

Overactivity of the dopaminergic system in the brain is considered to be a contributing factor to the development and symptomatology of schizophrenia. Therefore, the GABAergic control of dopamine functions was assessed by disrupting the gene encoding the α3 subunit of the GABA(A) receptor. α3 knocko...

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Detalhes bibliográficos
Main Authors: Yee, B. K., Keist, R., von Boehmer, L., Studer, R., Benke, D., Hagenbuch, N., Dong, Y., Malenka, R. C., Fritschy, J.-M., Bluethmann, H., Feldon, J., Möhler, H., Rudolph, U.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1288020/
https://ncbi.nlm.nih.gov/pubmed/16284244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508752102
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