Requirement of α(5)-GABA(A) Receptors for the Development of Tolerance to the Sedative Action of Diazepam in Mice

Despite its pharmacological relevance, the mechanism of the development of tolerance to the action of benzodiazepines is essentially unknown. The acute sedative action of diazepam is mediated via α(1)-GABA(A) receptors. Therefore, we tested whether chronic activation of these receptors by diazepam i...

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Vydáno v:J Neurosci
Hlavní autoři: van Rijnsoever, Carolien, Täuber, Marcus, Choulli, Mohamed Khaled, Keist, Ruth, Rudolph, Uwe, Mohler, Hanns, Fritschy, Jean Marc, Crestani, Florence
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2004
Témata:
Behavioral/Systems/Cognitive
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729721/
https://ncbi.nlm.nih.gov/pubmed/15282283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1067-04.2004
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