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Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK–STAT

Suppressor of cytokine signaling-1 (SOCS-1) is one of the negative-feedback regulators of Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling. We previously showed that SOCS-1 participates in LPS signaling, but it is not entirely clear yet how SOCS-1 suppresses LPS s...

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Bibliografiske detaljer
Main Authors: Kimura, Akihiro, Naka, Tetsuji, Muta, Tatsushi, Takeuchi, Osamu, Akira, Shizuo, Kawase, Ichiro, Kishimoto, Tadamitsu
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1288004/
https://ncbi.nlm.nih.gov/pubmed/16287972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508517102
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