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IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells

CD4(+) T cells producing IL-17 [T helper (Th)17], as distinct from Th1 or Th2 cells, have recently been shown to be associated with autoimmunity, but it is not entirely clear how Th17 cells are generated from naïve T cells. We demonstrate here that IL-6, but not TNF-α or IL-1β, can, in combination w...

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Autori principali: Kimura, Akihiro, Naka, Tetsuji, Kishimoto, Tadamitsu
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924582/
https://ncbi.nlm.nih.gov/pubmed/17623780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705268104
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