Inhibition of Human Immunodeficiency Virus Type 1 Integration by Diketo Derivatives

A series of diketo derivatives was found to inhibit human immunodeficiency virus type 1 (HIV-1) integrase activity. Only L-708,906 inhibited the replication of HIV-1(III(B)) (50% effective concentration, 12 μM), HIV-1 clinical strains, HIV-1 strains resistant to reverse transcriptase or fusion inhib...

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Detalhes bibliográficos
Main Authors: Pluymers, Wim, Pais, Godwin, Van Maele, Bénédicte, Pannecouque, Christophe, Fikkert, Valery, Burke, Jr., Terrence R., De Clercq, Erik, Witvrouw, Myriam, Neamati, Nouri, Debyser, Zeger
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2002
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC128766/
https://ncbi.nlm.nih.gov/pubmed/12234864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.10.3292-3297.2002
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