Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCθ in T lymphocytes

Phosphopeptide mapping identified a major autophosphorylation site, phospho (p)Thr-219, between the tandem C1 domains of the regulatory fragment in protein kinase C (PKC)θ. Confirmation of this identification was derived using (p)Thr-219 antisera that reacted with endogenous PKCθ in primary CD3(+) T...

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Main Authors: Thuille, Nikolaus, Heit, Isabelle, Fresser, Friedrich, Krumböck, Nina, Bauer, Birgit, Leuthaeusser, Sabine, Dammeier, Sascha, Graham, Caroline, Copeland, Terry D, Shaw, Steve, Baier, Gottfried
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283955/
https://ncbi.nlm.nih.gov/pubmed/16252004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600856
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