Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks

Photolyase transgenic mice have opened new avenues to improve our understanding of the cytotoxic effects of ultraviolet (UV) light on skin by providing a means to selectively remove either cyclobutane pyrimidine dimers (CPDs) or pyrimidine (6-4) pyrimidone photoproducts. Here, we have taken a genomi...

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Detalhes bibliográficos
Main Authors: Garinis, George A, Mitchell, James R, Moorhouse, Michael J, Hanada, Katsuhiro, de Waard, Harm, Vandeputte, Dimitri, Jans, Judith, Brand, Karl, Smid, Marcel, van der Spek, Peter J, Hoeijmakers, Jan H J, Kanaar, Roland, van der Horst, Gijsbertus T J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283948/
https://ncbi.nlm.nih.gov/pubmed/16252008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600849
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