Differential Role of Basal Keratinocytes in UV-Induced Immunosuppression and Skin Cancer

Cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs) comprise major UV-induced photolesions. If left unrepaired, these lesions can induce mutations and skin cancer, which is facilitated by UV-induced immunosuppression. Yet the contribution of lesion and cell type specificity to the ha...

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Main Authors: Jans, Judith, Garinis, George A., Schul, Wouter, van Oudenaren, Adri, Moorhouse, Michael, Smid, Marcel, Sert, Yurda-Gul, van der Velde, Albertina, Rijksen, Yvonne, de Gruijl, Frank R., van der Spek, Peter J., Yasui, Akira, Hoeijmakers, Jan H. J., Leenen, Pieter J. M., van der Horst, Gijsbertus T. J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636796/
https://ncbi.nlm.nih.gov/pubmed/16966369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00807-06
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