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Deleterious mutations in small subunit ribosomal RNA identify functional sites and potential targets for antibiotics

Many clinically useful antibiotics interfere with protein synthesis in bacterial pathogens by inhibiting ribosome function. The sites of action of known drugs are limited in number, are composed primarily of ribosomal RNA (rRNA), and coincide with functionally critical centers of the ribosome. Nucle...

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Bibliografiska uppgifter
Huvudupphovsmän: Yassin, Aymen, Fredrick, Kurt, Mankin, Alexander S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2005
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283848/
https://ncbi.nlm.nih.gov/pubmed/16269538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508444102
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