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Deleterious mutations in small subunit ribosomal RNA identify functional sites and potential targets for antibiotics
Many clinically useful antibiotics interfere with protein synthesis in bacterial pathogens by inhibiting ribosome function. The sites of action of known drugs are limited in number, are composed primarily of ribosomal RNA (rRNA), and coincide with functionally critical centers of the ribosome. Nucle...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2005
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1283848/ https://ncbi.nlm.nih.gov/pubmed/16269538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508444102 |
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